姓名:何华
学科:纳米医学
系别:预防兽医系
电话/传真:
电子邮件:hehua1123@126.com
通讯地址:郑州市郑东新区龙子湖高校园区15号 河南农业大学龙子湖校区第一实验楼QY千亿球友会网站 450046
简介
何华,女,博士,河南农业大学“拔尖人才”,校聘教授、硕士研究生导师,1989年生,河南平顶山人。目前主要承担课程有《生物技术进展》。科研上主持国家自然科学基金青年基金项目(26万元)、河南农业大学“拔尖人才”启动经费(200万元)。
在国际权威期刊上发表论文19篇,其中以第一作者在 ACS Nano、Adv Funct Mater 、Biomaterials 、Nanoscale 、Biomacromolecules发表论文6篇,H因子12,文章总引用数次528,获中国授权发明专利1项。
教授课程
生物技术进展,畜牧微生物学
研究领域
纳米佐剂,新型动物疾病防控纳米疫苗,仿生递送系统
学历及培训经历
2015.9-2018.6:苏州大学 化学 博士2012.9-2015.6:苏州大学 化学 硕士
2008.9-2012.6:信阳师范学院 化学 学士
工作经历
2019.5-至今:QY千亿球友会网站 校聘教授
承担科研项目情况
1. 河南农业大学拔尖人才项目,主持,200万2. 超高载药量乏氧响应性仿生纳米药物的构建及其用于晚期乳腺癌靶向治疗的研究,国家自然科学基金,主持,26万
3. 光动力调控的超高载药量肿瘤微环境响应性仿生纳米药物用于乳腺癌靶向治疗的研究,河南省科技攻关,主持,10万
4. 新型动物疾病防控纳米疫苗,河南农业大学兽医学科科技创新英才培育计划,主持,30万
代表论著(*通讯作者)
1. Y.N. Wang, J. Huo, S. Li, R. Huang, D.P. Fan, H.H. Cheng, B. Wan, Y.K. Du, H. He*, G.P. Zhang*, Self-Rectifiable and Hypoxia-Assisted Chem-Photodynamic Nanoinhibitor for Synergistic Cancer Therapy, ACS Applied Materials& Interfaces, 2022, doi: 10.1021/acsami.1c23121. (IF: 9.22,一区)2. H. He, N. Zheng, Z.Y. Song, K.H. Kim, C. Yao, R.J. Zhang, C.L. Zhang, Y.H. Huang, F.M. Uckun, J.J. Cheng, Y.F. Zhang, L.C. Yin*, Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles, ACS Nano, 2016,10(2), 1859-1870. (IF: 13.942, 一区)
3. H. He, Y.B. Chen, Y.J. Li, Z.Y. Song, Y.N. Zhong, R.Y. Zhu, J.J. Cheng*, L.C. Yin*, Effective and Selective Anti-Cancer Protein Delivery via All-Functions-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering, Advanced Functional Materials, 2018, 1706710. (IF: 15.621, 一区)
4. J.H. Wang#, H. He#, X. Xu, X. Wang, Y.B. Chen, L.C. Yin*, Far-Red Light-Mediated Programmable Anti-Cancer Gene Delivery in Cooperation with Photodynamic Therapy, Biomaterials, 2018, 171, 72-82. (共同一作,IF: 10.273, 一区)
5. H. He, R.Y. Zhu, W. Sun*, K.M. Cai, Y.B. Chen*, L.C. Yin*, Selective Cancer Treatment via Photodynamic Sensitization of Hypoxia-Responsive Drug Delivery, Nanoscale, 2018, 10, 2856-2865. (IF: 6.97, 一区)
6. D.S. Cao#, H. He#, W. Li, J. Yan, J.H. Wu, M.Y. Yin, Y. Zhou, Z.C. Zhou, L.C. Yin*, A near-infrared light-controlled, oxygen-independent radical generating nano-system toward cancer therapy, Biomaterials Science, 2021, 9, 4054-4065 (IF: 6.84, 一区).
7. R.Y. Zhu#, H. He#, Y. Liu*, D.S. Cao, J. Yan, S.Z. Duan, Y.B. Chen*, L.C. Yin*, Cancer-Selective Bioreductive Chemotherapy Mediated by Dual Hypoxia-Responsive Nanomedicine upon Photodynamic TherapyInduced Hypoxia Aggravation, Biomacromolecules, 2019, 20, 2649−2656. (IF: 6.092, 二区)
8. H. He, Y.G. Bai, J.H. Wang, Q.R. Deng, L.P. Zhu, F.H. Meng, Z.Y. Zhong*, L.C. Yin*, Reversibly Cross-Linked Polyplexes Enable Cancer-Targeted Gene Delivery via Self-Promoted DNA Release and Self-Diminished Toxicity, Biomacromolecules, 2015, 16(4), 1390-1400.
9. H. Wang, R.B. Wang, K.M. Cai, H. He, Y. Liu, J. Yen, Z.Y. Wang, M. Xu, Y.W. Sun, X. Zhou, Q. Yin, L. Tang, I.T. Dobrucki, L.W. Dobrucki, E.J. Chaney, S.A. Boppart, T.M. Fan, S. Lezmi, X.S. Chen*, L.C. Yin*, J.J. Cheng*, Selective In Vivo Metabolic Cell-Labeling-Mediated Cancer Targeting, Nature Chemical Biology , 2017, 13(4), 415-425. (IF: 13.843, 一区)
10. Z.Y. Song, R.A. Mansbach, H. He, K.-C. Shih, R. Baumgartner, N. Zheng, X.C. Ba, Y.Z. Huang, D. Mani, Y. Liu, Y. Lin, M.-P. Nieh, A.L. Ferguson*, L.C. Yin*, J.J. Cheng*, Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands, Nature Communications, 2017, 8, 92. (IF: 12.353,一区)
S.X. Lv, Y.C. Wu, K.M. Cai, H. He, Y.J. Li, M. Lan, X.S. Chen, J.J. Cheng, L.C. Yin*, High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions, Journal of the American Chemical Society, 2018, 140 (4), 1235-1238. (IF: 14.695, 一区)
荣誉称号
河南农业大学拔尖人才
寄语动医学子
要平凡,但不平庸;要大胆,但不大意;要虚心,但不虚荣;要勇敢,但不蛮横。